Methyl ketones from carboxylic acids as valuable target molecules in the biorefinery

For the preparation of methyl ketones, cross Ketonic Decarboxylation, i.e., formation a ketone from two different carboxylic acids, and reketonization, transformation acid into employing as alkyl transfer agent, may be interesting alternatives to classical pathways involving metal-organic reagents. The fine chemical 2-undecanone was chosen model compound ketonic decarboxylation reketonization evaluated by Green Chemistry matrices, namely carbon atom efficiency e-factor. e-factor reaction decanoic with acetic less than five and, therewith, in acceptable range for bulk chemicals, when valorizing acetone (e.g., solvent) considering 90% solvent recycling. provided main product, 10-nonadecanone, detrimental effect on efficiency. By means labeling experiments it shown that is significantly faster reaction. studied in-situ operando IR spectroscopy. Thereby found surface covered acid. lack adsorption clear drawback acids. To improve outcome, its sustainability possibility has stabilize molecules presence